FRET-based mapping of calmodulin bound to the RyR1 Ca(2+) release channel

Calmodulin (CaM) functions as a regulatory subunit of ryanodine receptor (RyR) channels, modulating channel activity in response to changing [Ca(2+)](i). To investigate the structural basis of CaM regulation of the RyR1 isoform, we used site-directed labeling of channel regulatory subunits and fluor...

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Bibliographic Details
Main Authors: Cornea, Razvan L., Nitu, Florentin, Gruber, Simon, Kohler, Katherine, Satzer, Michael, Thomas, David D., Fruen, Bradley R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662960/
https://ncbi.nlm.nih.gov/pubmed/19332786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813010106
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