Mapping the Ryanodine Receptor FK506-binding Protein Subunit Using Fluorescence Resonance Energy Transfer

The 12-kDa FK506-binding proteins (FKBP12 and FKBP12.6) are regulatory subunits of ryanodine receptor (RyR) Ca(2+) release channels. To investigate the structural basis of FKBP interactions with the RyR1 and RyR2 isoforms, we used site-directed fluorescent labeling of FKBP12.6, ligand binding measur...

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Detalhes bibliográficos
Main Authors: Cornea, Razvan L., Nitu, Florentin R., Samsó, Montserrat, Thomas, David D., Fruen, Bradley R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885200/
https://ncbi.nlm.nih.gov/pubmed/20404344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.066944
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