Localization of the Dantrolene-binding Sequence near the FK506-binding Protein-binding Site in the Three-dimensional Structure of the Ryanodine Receptor

Dantrolene is believed to stabilize interdomain interactions between the NH(2)-terminal and central regions of ryanodine receptors by binding to the NH(2)-terminal residues 590–609 in skeletal ryanodine receptor (RyR1) and residues 601–620 in cardiac ryanodine receptor (RyR2). To gain further insigh...

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Autores principales: Wang, Ruiwu, Zhong, Xiaowei, Meng, Xing, Koop, Andrea, Tian, Xixi, Jones, Peter P., Fruen, Bradley R., Wagenknecht, Terence, Liu, Zheng, Chen, S. R. Wayne
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Molecular Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069424/
https://ncbi.nlm.nih.gov/pubmed/21262961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194316
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