The α Subunit of the G Protein G(13) Regulates Activity of One or More Gli Transcription Factors Independently of Smoothened

par Douglas, Andrew E., Heim, Jennifer A., Shen, Feng, Almada, Luciana L., Riobo, Natalia A., Fernández-Zapico, Martin E., Manning, David R.
Publié 2011

GLI2 Transcription Factor Mediates Cytokine Cross-talk in the Tumor Microenvironment

par Elsawa, Sherine F., Almada, Luciana L., Ziesmer, Steven C., Novak, Anne J., Witzig, Thomas E., Ansell, Stephen M., Fernandez-Zapico, Martin E.
Publié 2011

Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion

par Jalan-Sakrikar, Nidhi, De Assuncao, Thiago M., Lu, Jie, Almada, Luciana L., Lomberk, Gwen, Fernandez-Zapico, Martin E., Urrutia, Raul, Huebert, Robert C.
Publié dans PLoS One (2016)

Targeting pancreatic cancer metastasis by inhibition of Vav1, a driver of tumor cell invasion

par Razidlo, Gina L., Magnine, Christopher, Sletten, Arthur C., Hurley, Rachel M., Almada, Luciana L., Fernandez-Zapico, Martin E., Ji, Baoan, McNiven, Mark A.
Publié dans Cancer Res (2015)

Stromal Gli signaling regulates the activity and differentiation of prostate stem and progenitor cells

par Li, Qianjin, Alsaidan, Omar A., Rai, Sumit, Wu, Meng, Shen, Huifeng, Beharry, Zanna, Almada, Luciana L., Fernandez-Zapico, Martin E., Wang, Lianchun, Cai, Houjian
Publié dans J Biol Chem (2018)

Combinatorial Chemoprevention Reveals a Novel Smoothened Independent Role of GLI1 in Esophageal Carcinogenesis

par Rizvi, Sumera, DeMars, Cathrine J., Comba, Andrea, Gainullin, Vladimir, Rizvi, Zaheer, Almada, Luciana L., Wang, Kenneth, Lomberk, Gwen, Fernández-Zapico, Martin E., Buttar, Navtej S.
Publié 2010

The transcription factor GLI1 cooperates with the chromatin remodeler SMARCA2 to regulate chromatin accessibility at distal DNA regulatory elements

par Safgren, Stephanie L., Olson, Rachel L. O., Vrabel, Anne M., Almada, Luciana L., Marks, David L., Hernandez-Alvarado, Nelmary, Gaspar-Maia, Alexandre, Fernandez-Zapico, Martin E.
Publié dans J Biol Chem (2020)

Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity

par Elsawa, Sherine F., Novak, Anne J., Ziesmer, Steven C., Almada, Luciana L., Hodge, Lucy S., Grote, Deanna M., Witzig, Thomas E., Fernandez-Zapico, Martin E., Ansell, Stephen M.
Publié 2011

The Transcription Factor GLI1 Interacts with SMAD Proteins to Modulate Transforming Growth Factor β-Induced Gene Expression in a p300/CREB-binding Protein-associated Factor (PCAF)-...

par Nye, Monica D., Almada, Luciana L., Fernandez-Barrena, Maite G., Marks, David L., Elsawa, Sherine F., Vrabel, Anne, Tolosa, Ezequiel J., Ellenrieder, Volker, Fernandez-Zapico, Martin E.
Publié 2014

GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells

par Joost, Simon, Almada, Luciana L., Rohnalter, Verena, Holz, Philipp S., Vrabel, Anne M., Fernandez-Barrena, Maite G., McWilliams, Robert R., Krause, Michael, Fernandez-Zapico, Martin E., Lauth, Matthias
Publié 2011

Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation

par Mills, Lisa D., Zhang, Yaqing, Marler, Ronald J., Herreros-Villanueva, Marta, Zhang, Lizhi, Almada, Luciana L., Couch, Fergus, Wetmore, Cynthia, Pasca di Magliano, Marina, Fernandez-Zapico, Martin E.
Publié 2013

Novel AKT1-GLI3-VMP1 Pathway Mediates KRAS Oncogene-induced Autophagy in Cancer Cells

par Lo Ré, Andrea E., Fernández-Barrena, Maite G., Almada, Luciana L., Mills, Lisa D., Elsawa, Sherine F., Lund, George, Ropolo, Alejandro, Molejon, Maria I., Vaccaro, Maria I., Fernandez-Zapico, Martin E.
Publié 2012

Modulation of the IL-6 Receptor α Underlies GLI2-mediated regulation of Immunoglobulin Secretion in Waldenström macroglobulinemia cells

par Jackson, David A., Smith, Timothy D., Amarsaikhan, Nansalmaa, Han, Weiguo, Neil, Matthew S., Boi, Shannon K., Vrabel, Anne M., Tolosa, Ezequiel J., Almada, Luciana L., Fernandez-Zapico, Martin E., Elsawa, Sherine F.
Publié dans J Immunol (2015)

TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ

par McCleary-Wheeler, Angela L, Paradise, Brooke D, Almada, Luciana L, Carlson, Annika J, Marks, David L, Vrabel, Anne, Vera, Renzo E, Sigafoos, Ashley N, Olson, Rachel L, Fernandez-Zapico, Martin E
Publié dans Nucleic Acids Res (2020)

A Functional Family-Wide Screening of SP/KLF Proteins Identifies a Subset of Suppressors of KRAS-Mediated Cell Growth

par Fernandez-Zapico, Martin E., Lomberk, Gwen A., Tsuji, Shoichiro, DeMars, Cathrine J., Bardsley, Michael R., Lin, Yi-Hui, Almada, Luciana L., Han, Jing-Jing, Mukhopadhyay, Debabrata, Ordog, Tamas, Buttar, Navtej S., Urrutia, Raul
Publié 2011

Identification and characterization of a novel promoter for the human ANO1 gene regulated by the transcription factor signal transducer and activator of transcription 6 (STAT6)

par Mazzone, Amelia, Gibbons, Simon J., Bernard, Cheryl E., Nowsheen, Somaira, Middha, Sumit, Almada, Luciana L., Ordog, Tamas, Kendrick, Michael L., Reid Lombardo, KMarie, Shen, K. Robert, Galietta, Luis J. V., Fernandez-Zapico, Martin E., Farrugia, Gianrico
Publié dans FASEB J (2015)

Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism

par Bednar, Filip, Schofield, Heather K., Collins, Meredith A., Yan, Wei, Zhang, Yaqing, Shyam, Nikhil, Eberle, Jaime A., Almada, Luciana L., Olive, Kenneth P., Bardeesy, Nabeel, Fernandez-Zapico, Martin E., Nakada, Daisuke, Simeone, Diane M., Morrison, Sean J., Pasca di Magliano, Marina
Publié dans Carcinogenesis (2015)

Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidon...

par Comba, Andrea, Almada, Luciana L., Tolosa, Ezequiel J., Iguchi, Eriko, Marks, David L., Vara Messler, Marianela, Silva, Renata, Fernandez-Barrena, Maite G., Enriquez-Hesles, Elisa, Vrabel, Anne L., Botta, Bruno, Di Marcotulio, Lucia, Ellenrieder, Volker, Eynard, Aldo R., Pasqualini, Maria E., Fernandez-Zapico, Martin E.
Publié dans J Biol Chem (2016)

4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells

par Yun, Seongseok, Vincelette, Nicole D., Knorr, Katherine L. B., Almada, Luciana L., Schneider, Paula A., Peterson, Kevin L., Flatten, Karen S., Dai, Haiming, Pratz, Keith W., Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Hendrickson, Andrea E. Wahner, Fernandez-Zapico, Martin E., Kaufmann, Scott H.
Publié dans Blood (2016)

The histone Lysine Methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming

par Koutsioumpa, Marina, Hatziapostolou, Maria, Polytarchou, Christos, Tolosa, Ezequiel J., Almada, Luciana L., Mahurkar-Joshi, Swapna, Williams, Jennifer, Tirado-Rodriguez, Belen, Huerta-Yepez, Sara, Karavias, Dimitrios, Kourea, Helen, Poultsides, George A., Struhl, Kevin, Dawson, David W., Donahue, Timothy R., Fernandez-Zapico, Martin E., lliopoulos, Dimitrios
Publié dans Gut (2018)