4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells

The mammalian target of rapamycin (mTOR), a kinase that regulates proliferation and apoptosis, has been extensively evaluated as a therapeutic target in multiple malignancies. Rapamycin analogs, which partially inhibit mTOR complex 1 (mTORC1), exhibit immunosuppressive and limited antitumor activity...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Yun, Seongseok, Vincelette, Nicole D., Knorr, Katherine L. B., Almada, Luciana L., Schneider, Paula A., Peterson, Kevin L., Flatten, Karen S., Dai, Haiming, Pratz, Keith W., Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Hendrickson, Andrea E. Wahner, Fernandez-Zapico, Martin E., Kaufmann, Scott H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891953/
https://ncbi.nlm.nih.gov/pubmed/26917778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-02-629485
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