4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells

The mammalian target of rapamycin (mTOR), a kinase that regulates proliferation and apoptosis, has been extensively evaluated as a therapeutic target in multiple malignancies. Rapamycin analogs, which partially inhibit mTOR complex 1 (mTORC1), exhibit immunosuppressive and limited antitumor activity...

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Pubblicato in:Blood
Autori principali: Yun, Seongseok, Vincelette, Nicole D., Knorr, Katherine L. B., Almada, Luciana L., Schneider, Paula A., Peterson, Kevin L., Flatten, Karen S., Dai, Haiming, Pratz, Keith W., Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Hendrickson, Andrea E. Wahner, Fernandez-Zapico, Martin E., Kaufmann, Scott H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2016
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891953/
https://ncbi.nlm.nih.gov/pubmed/26917778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-02-629485
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