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Genetically defining the mechanism of Puma- and Bim-induced apoptosis
Using genetically modified mouse models, we report here that p53 upregulated modulator of apoptosis (Puma) and Bcl-2 interacting mediator of cell death (Bim), two pro-apoptotic members of the B-cell lymphoma protein-2 (Bcl-2) family of proteins, cooperate in causing bone marrow and gastrointestinal...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307979/ https://ncbi.nlm.nih.gov/pubmed/22015606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.136 |
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