Genetically defining the mechanism of Puma- and Bim-induced apoptosis

Using genetically modified mouse models, we report here that p53 upregulated modulator of apoptosis (Puma) and Bcl-2 interacting mediator of cell death (Bim), two pro-apoptotic members of the B-cell lymphoma protein-2 (Bcl-2) family of proteins, cooperate in causing bone marrow and gastrointestinal...

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Autors principals: Garrison, S P, Phillips, D C, Jeffers, J R, Chipuk, J E, Parsons, M J, Rehg, J E, Opferman, J T, Green, D R, Zambetti, G P
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307979/
https://ncbi.nlm.nih.gov/pubmed/22015606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.136
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