Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis

The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate that Puma deletion in the Eμ-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that ∼75%...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Garrison, Sean P., Jeffers, John R., Yang, Chunying, Nilsson, Jonas A., Hall, Mark A., Rehg, Jerold E., Yue, Wen, Yu, Jian, Zhang, Lin, Onciu, Mihaela, Sample, Jeffery T., Cleveland, John L., Zambetti, Gerard P.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology (ASM) 2008
विषय:
Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519737/
https://ncbi.nlm.nih.gov/pubmed/18573879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00907-07
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