Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis

The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate that Puma deletion in the Eμ-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that ∼75%...

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Huvudupphovsmän: Garrison, Sean P., Jeffers, John R., Yang, Chunying, Nilsson, Jonas A., Hall, Mark A., Rehg, Jerold E., Yue, Wen, Yu, Jian, Zhang, Lin, Onciu, Mihaela, Sample, Jeffery T., Cleveland, John L., Zambetti, Gerard P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519737/
https://ncbi.nlm.nih.gov/pubmed/18573879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00907-07
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