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Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis
The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate that Puma deletion in the Eμ-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that ∼75%...
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| Huvudupphovsmän: | , , , , , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Microbiology (ASM)
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519737/ https://ncbi.nlm.nih.gov/pubmed/18573879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00907-07 |
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