Skp2 directs Myc-mediated suppression of p27(Kip1) yet has modest effects on Myc-driven lymphomagenesis

The universal cyclin-Cdk inhibitor p27(Kip1) functions as a tumor suppressor and reduced levels of p27(Kip1) connote poor prognosis in several human malignancies. p27(Kip1) levels are predominately regulated by ubiquitin-mediated turnover of the protein, which is marked for destruction by the E3 ubi...

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Bibliographische Detailangaben
Hauptverfasser: Old, Jennifer B, Kratzat, Susanne, Hoellein, Alexander, Graf, Steffi, Nilsson, Jonas A, Nilsson, Lisa, Nakayama, Keiichi I, Peschel, Christian, Cleveland, John L, Keller, Ulrich B
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095030/
https://ncbi.nlm.nih.gov/pubmed/20197382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-09-0232
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