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SKP2 Oncogene Is a Direct MYC Target Gene and MYC Down-regulates p27(KIP1) through SKP2 in Human Leukemia Cells
SKP2 is the ubiquitin ligase subunit that targets p27(KIP1) (p27) for degradation. SKP2 is induced in the G(1)-S transit of the cell cycle, is frequently overexpressed in human cancer, and displays transformation activity in experimental models. Here we show that MYC induces SKP2 expression at the m...
Tallennettuna:
| Päätekijät: | , , , , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3059036/ https://ncbi.nlm.nih.gov/pubmed/21245140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165977 |
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