SKP2 Oncogene Is a Direct MYC Target Gene and MYC Down-regulates p27(KIP1) through SKP2 in Human Leukemia Cells

SKP2 is the ubiquitin ligase subunit that targets p27(KIP1) (p27) for degradation. SKP2 is induced in the G(1)-S transit of the cell cycle, is frequently overexpressed in human cancer, and displays transformation activity in experimental models. Here we show that MYC induces SKP2 expression at the m...

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Main Authors: Bretones, Gabriel, Acosta, Juan C., Caraballo, Juan M., Ferrándiz, Nuria, Gómez-Casares, M. Teresa, Albajar, Marta, Blanco, Rosa, Ruiz, Paula, Hung, Wen-Chun, Albero, M. Pilar, Perez-Roger, Ignacio, León, Javier
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2011
נושאים:
Gene Regulation
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059036/
https://ncbi.nlm.nih.gov/pubmed/21245140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165977
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