The Amelioration of Renal Damage in Skp2-Deficient Mice Canceled by p27 (Kip1) Deficiency in Skp2(−/−) p27(−/−) Mice

SCF-Skp2 E3 ubiquitin ligase (Skp2 hereafter) targets several cell cycle regulatory proteins for degradation via the ubiquitin-dependent pathway. However, the target-specific physiological functions of Skp2 have not been fully elucidated in kidney diseases. We previously reported an increase in Skp2...

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Main Authors: Suzuki, Sayuri, Fukasawa, Hirotaka, Misaki, Taro, Togawa, Akashi, Ohashi, Naro, Kitagawa, Kyoko, Kotake, Yojiro, Liu, Ning, Niida, Hiroyuki, Nakayama, Keiko, Nakayama, Keiichi I., Yamamoto, Tatsuo, Kitagawa, Masatoshi
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338689/
https://ncbi.nlm.nih.gov/pubmed/22558406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036249
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