Roles of the Skp2/p27 axis in the progression of chronic nephropathy

S-phase kinase-associated protein 2 (Skp2) is an F-box protein component of the Skp/Cullin/F-box-type E3 ubiquitin ligase that targets several cell cycle regulatory proteins for degradation through the ubiquitin-dependent pathway. Skp2-mediated degradation of p27, a cyclin-dependent kinase inhibitor...

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Bibliographic Details
Main Authors: Suzuki, Sayuri, Ohashi, Naro, Kitagawa, Masatoshi
Format: Artigo
Language:Inglês
Published: Springer Basel 2012
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753466/
https://ncbi.nlm.nih.gov/pubmed/23255047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-012-1232-x
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