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Renal Damage in Obstructive Nephropathy Is Decreased in Skp2-Deficient Mice
Ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27 mediated by SCF-Skp2 ubiquitin ligase is involved in cell cycle regulation. Proliferation of tubular cells is a characteristic feature in obstructed kidneys of unilateral ureteral obstruction. Comparing Skp2(+/+) mice with...
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| Main Authors: | , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Investigative Pathology
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1934544/ https://ncbi.nlm.nih.gov/pubmed/17620370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070279 |
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