Renal Damage in Obstructive Nephropathy Is Decreased in Skp2-Deficient Mice

Ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27 mediated by SCF-Skp2 ubiquitin ligase is involved in cell cycle regulation. Proliferation of tubular cells is a characteristic feature in obstructed kidneys of unilateral ureteral obstruction. Comparing Skp2(+/+) mice with...

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Main Authors: Suzuki, Sayuri, Fukasawa, Hirotaka, Kitagawa, Kyoko, Uchida, Chiharu, Hattori, Takayuki, Isobe, Tomoyasu, Oda, Toshiaki, Misaki, Taro, Ohashi, Naro, Nakayama, Keiko, Nakayama, Keiichi I., Hishida, Akira, Yamamoto, Tatsuo, Kitagawa, Masatoshi
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934544/
https://ncbi.nlm.nih.gov/pubmed/17620370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070279
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