NDRG2 facilitates colorectal cancer differentiation through the regulation of Skp2-p21/p27 axis

Poorly differentiated colorectal cancers (CRCs) are more aggressive and lack targeted therapies. We and others previously reported the predominant role of tumor-suppressor NDRG2 in promoting CRC differentiation, but the underlying mechanism is largely unknown. Herein, we demonstrate that NDRG2 induc...

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Pubblicato in:Oncogene
Autori principali: Shen, Liangliang, Qu, Xuan, Li, Huichen, Xu, Chunsheng, Wei, Mengying, Wang, Qinhao, Ru, Yi, Liu, Bei, Xu, Yuqiao, Li, Kai, Hu, Junbi, Wang, Lifeng, Ma, Yongzheng, Li, Mengyang, Lai, Xiaofeng, Gao, Lei, Wu, Kaichun, Yao, Libo, Zheng, Jianyong, Zhang, Jian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874257/
https://ncbi.nlm.nih.gov/pubmed/29343851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0118-7
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