Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

The ubiquitin–proteasome pathway plays an important role in control of the abundance of cell cycle regulators. Mice lacking Skp2, an F-box protein and substrate recognition component of an Skp1–Cullin–F-box protein (SCF) ubiquitin ligase, were generated. Although Skp2(–/–) animals are viable, cells...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Nakayama, Keiko, Nagahama, Hiroyasu, Minamishima, Yohji A., Matsumoto, Masaki, Nakamichi, Ikuo, Kitagawa, Kyoko, Shirane, Michiko, Tsunematsu, Ryosuke, Tsukiyama, Tadasuke, Ishida, Noriko, Kitagawa, Masatoshi, Nakayama, Kei-ichi, Hatakeyama, Shigetsugu
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC305685/
https://ncbi.nlm.nih.gov/pubmed/10790373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.9.2069
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados