Interaction between Cyclin T1 and SCF(SKP2) Targets CDK9 for Ubiquitination and Degradation by the Proteasome

CDK9 paired with cyclin T1 forms the human P-TEFb complex and stimulates productive transcription through phosphorylation of the RNA polymerase II C-terminal domain. Here we report that CDK9 is ubiquitinated and degraded by the proteasome whereas cyclin T1 is stable. SCF(SKP2) was recruited to CDK9/...

詳細記述

保存先:
書誌詳細
主要な著者: Kiernan, Rosemary E., Emiliani, Stéphane, Nakayama, Keiko, Castro, Anna, Labbé, Jean Claude, Lorca, Thierry, Nakayama, Kei-ichi, Benkirane, Monsef
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2001
主題:
Gene Expression
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC99964/
https://ncbi.nlm.nih.gov/pubmed/11689688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.23.7956-7970.2001
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料