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Interaction between Cyclin T1 and SCF(SKP2) Targets CDK9 for Ubiquitination and Degradation by the Proteasome
CDK9 paired with cyclin T1 forms the human P-TEFb complex and stimulates productive transcription through phosphorylation of the RNA polymerase II C-terminal domain. Here we report that CDK9 is ubiquitinated and degraded by the proteasome whereas cyclin T1 is stable. SCF(SKP2) was recruited to CDK9/...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC99964/ https://ncbi.nlm.nih.gov/pubmed/11689688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.23.7956-7970.2001 |
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