Interaction between Cyclin T1 and SCF(SKP2) Targets CDK9 for Ubiquitination and Degradation by the Proteasome

CDK9 paired with cyclin T1 forms the human P-TEFb complex and stimulates productive transcription through phosphorylation of the RNA polymerase II C-terminal domain. Here we report that CDK9 is ubiquitinated and degraded by the proteasome whereas cyclin T1 is stable. SCF(SKP2) was recruited to CDK9/...

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Bibliographische Detailangaben
Hauptverfasser: Kiernan, Rosemary E., Emiliani, Stéphane, Nakayama, Keiko, Castro, Anna, Labbé, Jean Claude, Lorca, Thierry, Nakayama, Kei-ichi, Benkirane, Monsef
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC99964/
https://ncbi.nlm.nih.gov/pubmed/11689688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.23.7956-7970.2001
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