Interaction between Cyclin T1 and SCF(SKP2) Targets CDK9 for Ubiquitination and Degradation by the Proteasome

CDK9 paired with cyclin T1 forms the human P-TEFb complex and stimulates productive transcription through phosphorylation of the RNA polymerase II C-terminal domain. Here we report that CDK9 is ubiquitinated and degraded by the proteasome whereas cyclin T1 is stable. SCF(SKP2) was recruited to CDK9/...

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書目詳細資料

發表在:	Mol Cell Biol
Principais autores:	Kiernan, Rosemary E., Emiliani, Stéphane, Nakayama, Keiko, Castro, Anna, Labbé, Jean Claude, Lorca, Thierry, Nakayama, Kei-ichi, Benkirane, Monsef
格式:	Artigo
語言:	Inglês
出版:	Taylor & Francis 2001
主題:	Gene Expression
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99964/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11689688/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.23.7956-7970.2001
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