Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

The ubiquitin–proteasome pathway plays an important role in control of the abundance of cell cycle regulators. Mice lacking Skp2, an F-box protein and substrate recognition component of an Skp1–Cullin–F-box protein (SCF) ubiquitin ligase, were generated. Although Skp2(–/–) animals are viable, cells...

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Main Authors: Nakayama, Keiko, Nagahama, Hiroyasu, Minamishima, Yohji A., Matsumoto, Masaki, Nakamichi, Ikuo, Kitagawa, Kyoko, Shirane, Michiko, Tsunematsu, Ryosuke, Tsukiyama, Tadasuke, Ishida, Noriko, Kitagawa, Masatoshi, Nakayama, Kei-ichi, Hatakeyama, Shigetsugu
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2000
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC305685/
https://ncbi.nlm.nih.gov/pubmed/10790373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.9.2069
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