Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

The ubiquitin–proteasome pathway plays an important role in control of the abundance of cell cycle regulators. Mice lacking Skp2, an F-box protein and substrate recognition component of an Skp1–Cullin–F-box protein (SCF) ubiquitin ligase, were generated. Although Skp2(–/–) animals are viable, cells...

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Pubblicato in:	EMBO J
Autori principali:	Nakayama, Keiko, Nagahama, Hiroyasu, Minamishima, Yohji A., Matsumoto, Masaki, Nakamichi, Ikuo, Kitagawa, Kyoko, Shirane, Michiko, Tsunematsu, Ryosuke, Tsukiyama, Tadasuke, Ishida, Noriko, Kitagawa, Masatoshi, Nakayama, Kei-ichi, Hatakeyama, Shigetsugu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2000
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305685/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10790373/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.9.2069
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