High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle

Myc (c-Myc) counteracts p27 effects, and low p27 usually correlates with high Myc expression in human cancer. However there is no information on the co-expression of both genes in chronic lymphocytic leukemia (CLL). We found a lack of correlation between RNA and protein levels of p27 and Myc in CLL...

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Autors principals: Caraballo, Juan M., Acosta, Juan C., Cortés, Miguel A., Albajar, Marta, Gómez-Casares, M. Teresa, Batlle-López, Ana, Cuadrado, M. Angeles, Onaindia, Arantza, Bretones, Gabriel, Llorca, Javier, Piris, Miguel A., Colomer, Dolors, León, Javier
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148092/
https://ncbi.nlm.nih.gov/pubmed/25051361
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