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Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27
Cell cycle stimulation is a major transforming mechanism of Myc oncoprotein. This is achieved through at least three concomitant mechanisms: upregulation of cyclins and Cdks, downregulation of the Cdk inhibitors p15 and p21 and the degradation of p27. The Myc-p27 antagonism has been shown to be rele...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6904551/ https://ncbi.nlm.nih.gov/pubmed/31822694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54917-1 |
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