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Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27
Cell cycle stimulation is a major transforming mechanism of Myc oncoprotein. This is achieved through at least three concomitant mechanisms: upregulation of cyclins and Cdks, downregulation of the Cdk inhibitors p15 and p21 and the degradation of p27. The Myc-p27 antagonism has been shown to be rele...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6904551/ https://ncbi.nlm.nih.gov/pubmed/31822694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54917-1 |
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