Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27

Cell cycle stimulation is a major transforming mechanism of Myc oncoprotein. This is achieved through at least three concomitant mechanisms: upregulation of cyclins and Cdks, downregulation of the Cdk inhibitors p15 and p21 and the degradation of p27. The Myc-p27 antagonism has been shown to be rele...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: García-Gutiérrez, Lucía, Bretones, Gabriel, Molina, Ester, Arechaga, Ignacio, Symonds, Catherine, Acosta, Juan C., Blanco, Rosa, Fernández, Adrián, Alonso, Leticia, Sicinski, Piotr, Barbacid, Mariano, Santamaría, David, León, Javier
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904551/
https://ncbi.nlm.nih.gov/pubmed/31822694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54917-1
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