Myc Inhibits p27-Induced Erythroid Differentiation of Leukemia Cells by Repressing Erythroid Master Genes without Reversing p27-Mediated Cell Cycle Arrest

Inhibition of differentiation has been proposed as an important mechanism for Myc-induced tumorigenesis, but the mechanisms involved are unclear. We have established a genetically defined differentiation model in human leukemia K562 cells by conditional expression of the cyclin-dependent kinase (Cdk...

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Autori principali: Acosta, Juan C., Ferrándiz, Nuria, Bretones, Gabriel, Torrano, Verónica, Blanco, Rosa, Richard, Carlos, O'Connell, Brenda, Sedivy, John, Delgado, M. Dolores, León, Javier
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593424/
https://ncbi.nlm.nih.gov/pubmed/18838534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00752-08
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