Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

The MYC and RAS oncogenes are frequently activated in cancer and, together, are sufficient to transform rodent cells. The basis for this cooperativity remains unclear. We found that although Ras interfered with Myc-induced apoptosis, Myc repressed Ras-induced senescence, together abrogating two main...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hydbring, Per, Bahram, Fuad, Su, Yingtao, Tronnersjö, Susanna, Högstrand, Kari, von der Lehr, Natalie, Sharifi, Hamid Reza, Lilischkis, Richard, Hein, Nadine, Wu, Siqin, Vervoorts, Jörg, Henriksson, Marie, Grandien, Alf, Lüscher, Bernhard, Larsson, Lars-Gunnar
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2009
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806698/
https://ncbi.nlm.nih.gov/pubmed/19966300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900121106
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