Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

The MYC and RAS oncogenes are frequently activated in cancer and, together, are sufficient to transform rodent cells. The basis for this cooperativity remains unclear. We found that although Ras interfered with Myc-induced apoptosis, Myc repressed Ras-induced senescence, together abrogating two main...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hydbring, Per, Bahram, Fuad, Su, Yingtao, Tronnersjö, Susanna, Högstrand, Kari, von der Lehr, Natalie, Sharifi, Hamid Reza, Lilischkis, Richard, Hein, Nadine, Wu, Siqin, Vervoorts, Jörg, Henriksson, Marie, Grandien, Alf, Lüscher, Bernhard, Larsson, Lars-Gunnar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2009
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806698/
https://ncbi.nlm.nih.gov/pubmed/19966300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900121106
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