Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

The MYC and RAS oncogenes are frequently activated in cancer and, together, are sufficient to transform rodent cells. The basis for this cooperativity remains unclear. We found that although Ras interfered with Myc-induced apoptosis, Myc repressed Ras-induced senescence, together abrogating two main...

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Hlavní autoři: Hydbring, Per, Bahram, Fuad, Su, Yingtao, Tronnersjö, Susanna, Högstrand, Kari, von der Lehr, Natalie, Sharifi, Hamid Reza, Lilischkis, Richard, Hein, Nadine, Wu, Siqin, Vervoorts, Jörg, Henriksson, Marie, Grandien, Alf, Lüscher, Bernhard, Larsson, Lars-Gunnar
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806698/
https://ncbi.nlm.nih.gov/pubmed/19966300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900121106
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