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Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation
The MYC and RAS oncogenes are frequently activated in cancer and, together, are sufficient to transform rodent cells. The basis for this cooperativity remains unclear. We found that although Ras interfered with Myc-induced apoptosis, Myc repressed Ras-induced senescence, together abrogating two main...
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| Główni autorzy: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2806698/ https://ncbi.nlm.nih.gov/pubmed/19966300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900121106 |
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