Myc targets Cks1 to provoke the suppression of p27(Kip1), proliferation and lymphomagenesis

Reduced levels of the cyclin-dependent kinase inhibitor p27(Kip1) connote poor prognosis in cancer. In human Burkitt lymphoma and in precancerous B cells and lymphomas arising in Eμ-Myc transgenic mice, p27(Kip1) expression is markedly reduced. We show that the transcription of the Cks1 component of...

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Detalhes bibliográficos
Main Authors: Keller, Ulrich B, Old, Jennifer B, Dorsey, Frank C, Nilsson, Jonas A, Nilsson, Lisa, MacLean, Kirsteen H, Chung, Linda, Yang, Chunying, Spruck, Charles, Boyd, Kelli, Reed, Steven I, Cleveland, John L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868903/
https://ncbi.nlm.nih.gov/pubmed/17464290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601691
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