Cks1 Promotion of S Phase Entry and Proliferation Is Independent of p27(Kip1) Suppression

Cks1 is an activator of the SCF(Skp2) ubiquitin ligase complex that targets the cell cycle inhibitor p27(Kip1) for degradation. The loss of Cks1 results in p27(Kip1) accumulation and decreased proliferation and inhibits tumorigenesis. We identify here a function of Cks1 in mammalian cell cycle regul...

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Detalhes bibliográficos
Main Authors: Hoellein, Alexander, Graf, Steffi, Bassermann, Florian, Schoeffmann, Stephanie, Platz, Ulrich, Hölzlwimmer, Gabriele, Kröger, Monika, Peschel, Christian, Oostendorp, Robert, Quintanilla-Fend, Leticia, Keller, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434501/
https://ncbi.nlm.nih.gov/pubmed/22508990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06771-11
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