Cks1 Promotion of S Phase Entry and Proliferation Is Independent of p27(Kip1) Suppression

Cks1 is an activator of the SCF(Skp2) ubiquitin ligase complex that targets the cell cycle inhibitor p27(Kip1) for degradation. The loss of Cks1 results in p27(Kip1) accumulation and decreased proliferation and inhibits tumorigenesis. We identify here a function of Cks1 in mammalian cell cycle regul...

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Main Authors: Hoellein, Alexander, Graf, Steffi, Bassermann, Florian, Schoeffmann, Stephanie, Platz, Ulrich, Hölzlwimmer, Gabriele, Kröger, Monika, Peschel, Christian, Oostendorp, Robert, Quintanilla-Fend, Leticia, Keller, Ulrich
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434501/
https://ncbi.nlm.nih.gov/pubmed/22508990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06771-11
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