Cks1 Is Required for Tumor Cell Proliferation but Not Sufficient to Induce Hematopoietic Malignancies

The Cks1 component of the SCF(Skp2) complex is necessary for p27(Kip1) ubiquitylation and degradation. Cks1 expression is elevated in various B cell malignancies including Burkitt lymphoma and multiple myeloma. We have previously shown that loss of Cks1 results in elevated p27(Kip1) levels and delay...

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Main Authors: Kratzat, Susanne, Nikolova, Viktoriya, Miething, Cornelius, Hoellein, Alexander, Schoeffmann, Stephanie, Gorka, Oliver, Pietschmann, Elke, Illert, Anna-Lena, Ruland, Jürgen, Peschel, Christian, Nilsson, Jonas, Duyster, Justus, Keller, Ulrich
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356264/
https://ncbi.nlm.nih.gov/pubmed/22624029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037433
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