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Cks1 Promotion of S Phase Entry and Proliferation Is Independent of p27(Kip1) Suppression
Cks1 is an activator of the SCF(Skp2) ubiquitin ligase complex that targets the cell cycle inhibitor p27(Kip1) for degradation. The loss of Cks1 results in p27(Kip1) accumulation and decreased proliferation and inhibits tumorigenesis. We identify here a function of Cks1 in mammalian cell cycle regul...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3434501/ https://ncbi.nlm.nih.gov/pubmed/22508990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06771-11 |
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