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Cks1 Promotion of S Phase Entry and Proliferation Is Independent of p27(Kip1) Suppression
Cks1 is an activator of the SCF(Skp2) ubiquitin ligase complex that targets the cell cycle inhibitor p27(Kip1) for degradation. The loss of Cks1 results in p27(Kip1) accumulation and decreased proliferation and inhibits tumorigenesis. We identify here a function of Cks1 in mammalian cell cycle regul...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Society for Microbiology
2012
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3434501/ https://ncbi.nlm.nih.gov/pubmed/22508990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06771-11 |
| टैग : |
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