Germ-line mutations in p27(Kip1) cause a multiple endocrine neoplasia syndrome in rats and humans

MENX is a recessive multiple endocrine neoplasia-like syndrome in the rat. The tumor spectrum in MENX overlaps those of human multiple endocrine neoplasia (MEN) types 1 and 2. We mapped the MenX locus to the distal part of rat chromosome 4, excluding the homologs of the genes responsible for the MEN...

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Detalhes bibliográficos
Main Authors: Pellegata, Natalia S., Quintanilla-Martinez, Leticia, Siggelkow, Heide, Samson, Elenore, Bink, Karin, Höfler, Heinz, Fend, Falko, Graw, Jochen, Atkinson, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1622862/
https://ncbi.nlm.nih.gov/pubmed/17030811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603877103
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