Germ-line mutations in p27(Kip1) cause a multiple endocrine neoplasia syndrome in rats and humans

MENX is a recessive multiple endocrine neoplasia-like syndrome in the rat. The tumor spectrum in MENX overlaps those of human multiple endocrine neoplasia (MEN) types 1 and 2. We mapped the MenX locus to the distal part of rat chromosome 4, excluding the homologs of the genes responsible for the MEN...

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Bibliographic Details
Main Authors: Pellegata, Natalia S., Quintanilla-Martinez, Leticia, Siggelkow, Heide, Samson, Elenore, Bink, Karin, Höfler, Heinz, Fend, Falko, Graw, Jochen, Atkinson, Michael J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1622862/
https://ncbi.nlm.nih.gov/pubmed/17030811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603877103
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