CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis

The G1 kinase CDK4 is amplified or overexpressed in some human tumors and promotes tumorigenesis by inhibiting known tumor suppressors. Here, we report that CDK4 deficiency markedly accelerated lymphoma development in the Eμ-Myc transgenic mouse model of B lymphoma and that silencing or loss of CDK4...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lu, Yuanzhi, Wu, Yongsheng, Feng, Xiaoling, Shen, Rulong, Wang, Jing H., Fallahi, Mohammad, Li, Weimin, Yang, Chunying, Hankey, William, Zhao, Weiqiang, Ganju, Ramesh K., Li, Ming O., Cleveland, John L., Zou, Xianghong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2014
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973114/
https://ncbi.nlm.nih.gov/pubmed/24614102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63139
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