CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis

The G1 kinase CDK4 is amplified or overexpressed in some human tumors and promotes tumorigenesis by inhibiting known tumor suppressors. Here, we report that CDK4 deficiency markedly accelerated lymphoma development in the Eμ-Myc transgenic mouse model of B lymphoma and that silencing or loss of CDK4...

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Hlavní autoři: Lu, Yuanzhi, Wu, Yongsheng, Feng, Xiaoling, Shen, Rulong, Wang, Jing H., Fallahi, Mohammad, Li, Weimin, Yang, Chunying, Hankey, William, Zhao, Weiqiang, Ganju, Ramesh K., Li, Ming O., Cleveland, John L., Zou, Xianghong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973114/
https://ncbi.nlm.nih.gov/pubmed/24614102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63139
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