CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis

The G1 kinase CDK4 is amplified or overexpressed in some human tumors and promotes tumorigenesis by inhibiting known tumor suppressors. Here, we report that CDK4 deficiency markedly accelerated lymphoma development in the Eμ-Myc transgenic mouse model of B lymphoma and that silencing or loss of CDK4...

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Detalhes bibliográficos
Main Authors: Lu, Yuanzhi, Wu, Yongsheng, Feng, Xiaoling, Shen, Rulong, Wang, Jing H., Fallahi, Mohammad, Li, Weimin, Yang, Chunying, Hankey, William, Zhao, Weiqiang, Ganju, Ramesh K., Li, Ming O., Cleveland, John L., Zou, Xianghong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973114/
https://ncbi.nlm.nih.gov/pubmed/24614102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63139
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