TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ

The modulation of GLI2, an oncogenic transcription factor commonly upregulated in cancer, is in many cases not due to genetic defects, suggesting dysregulation through alternative mechanisms. The identity of these molecular events remains for the most part unknown. Here, we identified TFII-I as a no...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: McCleary-Wheeler, Angela L, Paradise, Brooke D, Almada, Luciana L, Carlson, Annika J, Marks, David L, Vrabel, Anne, Vera, Renzo E, Sigafoos, Ashley N, Olson, Rachel L, Fernandez-Zapico, Martin E
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367210/
https://ncbi.nlm.nih.gov/pubmed/32544250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa476
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