TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ

The modulation of GLI2, an oncogenic transcription factor commonly upregulated in cancer, is in many cases not due to genetic defects, suggesting dysregulation through alternative mechanisms. The identity of these molecular events remains for the most part unknown. Here, we identified TFII-I as a no...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: McCleary-Wheeler, Angela L, Paradise, Brooke D, Almada, Luciana L, Carlson, Annika J, Marks, David L, Vrabel, Anne, Vera, Renzo E, Sigafoos, Ashley N, Olson, Rachel L, Fernandez-Zapico, Martin E
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367210/
https://ncbi.nlm.nih.gov/pubmed/32544250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa476
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