Novel AKT1-GLI3-VMP1 Pathway Mediates KRAS Oncogene-induced Autophagy in Cancer Cells

Autophagy is an evolutionarily conserved degradation process of cytoplasmic cellular constituents. It has been suggested that autophagy plays a role in tumor promotion and progression downstream oncogenic pathways; however, the molecular mechanisms underlying this phenomenon have not been elucidated...

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Bibliographic Details
Main Authors: Lo Ré, Andrea E., Fernández-Barrena, Maite G., Almada, Luciana L., Mills, Lisa D., Elsawa, Sherine F., Lund, George, Ropolo, Alejandro, Molejon, Maria I., Vaccaro, Maria I., Fernandez-Zapico, Martin E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Bioenergetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408195/
https://ncbi.nlm.nih.gov/pubmed/22535956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.370809
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