The Transcription Factor GLI1 Interacts with SMAD Proteins to Modulate Transforming Growth Factor β-Induced Gene Expression in a p300/CREB-binding Protein-associated Factor (PCAF)-dependent Manner

The biological role of the transcription factor GLI1 in the regulation of tumor growth is well established; however, the molecular events modulating this phenomenon remain elusive. Here, we demonstrate a novel mechanism underlying the role of GLI1 as an effector of TGFβ signaling in the regulation o...

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Detalhes bibliográficos
Main Authors: Nye, Monica D., Almada, Luciana L., Fernandez-Barrena, Maite G., Marks, David L., Elsawa, Sherine F., Vrabel, Anne, Tolosa, Ezequiel J., Ellenrieder, Volker, Fernandez-Zapico, Martin E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140905/
https://ncbi.nlm.nih.gov/pubmed/24739390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545194
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