Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid

Numerous reports have demonstrated a tumor inhibitory effect of polyunsaturated fatty acids (PUFAs). However, the molecular mechanisms modulating this phenomenon are in part poorly understood. Here, we provide evidence of a novel antitumoral mechanism of the PUFA arachidonic acid (AA). In vivo and i...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Comba, Andrea, Almada, Luciana L., Tolosa, Ezequiel J., Iguchi, Eriko, Marks, David L., Vara Messler, Marianela, Silva, Renata, Fernandez-Barrena, Maite G., Enriquez-Hesles, Elisa, Vrabel, Anne L., Botta, Bruno, Di Marcotulio, Lucia, Ellenrieder, Volker, Eynard, Aldo R., Pasqualini, Maria E., Fernandez-Zapico, Martin E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4722469/
https://ncbi.nlm.nih.gov/pubmed/26601952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.691972
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