The α Subunit of the G Protein G(13) Regulates Activity of One or More Gli Transcription Factors Independently of Smoothened

Smoothened (Smo) is a seven-transmembrane (7-TM) receptor that is essential to most actions of the Hedgehog family of morphogens. We found previously that Smo couples to members of the G(i) family of heterotrimeric G proteins, which in some cases are integral although alone insufficient in the activ...

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Main Authors: Douglas, Andrew E., Heim, Jennifer A., Shen, Feng, Almada, Luciana L., Riobo, Natalia A., Fernández-Zapico, Martin E., Manning, David R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162432/
https://ncbi.nlm.nih.gov/pubmed/21757753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.219279
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