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Activation of heterotrimeric G proteins by Smoothened

The mechanisms by which the activation of Smoothened (Smo), a protein essential to the actions of the Hedgehog family of secreted proteins, is translated into signals that converge on the Gli transcription factors are not fully understood. The seven-transmembrane structure of Smo has long implied th...

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Bibliografiske detaljer
Main Authors: Riobo, Natalia A., Saucy, Berangere, DiLizio, Cherisse, Manning, David R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567926/
https://ncbi.nlm.nih.gov/pubmed/16885213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600880103
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