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Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner via coupling of Smoothened to G(i) proteins
The vertebrate Hedgehog (Hh) pathway has essential functions during development and tissue homeostasis during normal physiology while its dysregulation is a common theme in cancer. The Hh ligands (Sonic, Indian, and Desert Hh), bind to the receptors Patched1 and 2, resulting in inhibition of their r...
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| Veröffentlicht in: | Sci Signal |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5811764/ https://ncbi.nlm.nih.gov/pubmed/22114142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002396 |
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