Heterotrimeric G(i) Proteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration

Evidence supporting the functionality of Smoothened (SMO), an essential transducer in most pathways engaged by Hedgehog (Hh), as a G(i)-coupled receptor contrasts with the lack of an apparently consistent requirement for G(i) in Hh signal transduction. In the present study, we sought to evaluate the...

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Autors principals: Polizio, Ariel H., Chinchilla, Pilar, Chen, Xiaole, Kim, Sangbumn, Manning, David R., Riobo, Natalia A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103338/
https://ncbi.nlm.nih.gov/pubmed/21474452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.197111
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