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Smoothened Is a Fully Competent Activator of the Heterotrimeric G Protein G(i)

Smoothened (Smo) is a 7-transmembrane protein essential to the activation of Gli transcription factors (Gli) by hedgehog morphogens. The structure of Smo implies interactions with heterotrimeric G proteins, but the degree to which G proteins participate in the actions of hedgehogs remains controvers...

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Detalhes bibliográficos
Main Authors: Shen, Feng, Cheng, Lan, Douglas, Andrew E., Riobo, Natalia A., Manning, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583497/
https://ncbi.nlm.nih.gov/pubmed/23292797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.082511
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