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Smoothened Is a Fully Competent Activator of the Heterotrimeric G Protein G(i)
Smoothened (Smo) is a 7-transmembrane protein essential to the activation of Gli transcription factors (Gli) by hedgehog morphogens. The structure of Smo implies interactions with heterotrimeric G proteins, but the degree to which G proteins participate in the actions of hedgehogs remains controvers...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3583497/ https://ncbi.nlm.nih.gov/pubmed/23292797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.082511 |
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