Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation

Although the biological role of KRAS is clearly established in carcinogenesis, the molecular mechanisms underlying this phenomenon are not completely understood. In this study, we provide evidence of a novel signaling network regulated by the transcription factor GLI1 mediating KRAS-induced carcinog...

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Detalhes bibliográficos
Main Authors: Mills, Lisa D., Zhang, Yaqing, Marler, Ronald J., Herreros-Villanueva, Marta, Zhang, Lizhi, Almada, Luciana L., Couch, Fergus, Wetmore, Cynthia, Pasca di Magliano, Marina, Fernandez-Zapico, Martin E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636867/
https://ncbi.nlm.nih.gov/pubmed/23482563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438846
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