Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

Pancreatic cancer is almost invariably associated with mutations in the KRAS gene, most commonly KRAS(G12D), that result in a dominant-active form of the KRAS GTPase. However, how KRAS mutations promote pancreatic carcinogenesis is not fully understood, and whether oncogenic KRAS is required for the...

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Main Authors: Collins, Meredith A., Bednar, Filip, Zhang, Yaqing, Brisset, Jean-Christophe, Galbán, Stefanie, Galbán, Craig J., Rakshit, Sabita, Flannagan, Karen S., Adsay, N. Volkan, Pasca di Magliano, Marina
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266788/
https://ncbi.nlm.nih.gov/pubmed/22232209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59227
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