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Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
Pancreatic cancer is almost invariably associated with mutations in the KRAS gene, most commonly KRAS(G12D), that result in a dominant-active form of the KRAS GTPase. However, how KRAS mutations promote pancreatic carcinogenesis is not fully understood, and whether oncogenic KRAS is required for the...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical Investigation
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3266788/ https://ncbi.nlm.nih.gov/pubmed/22232209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59227 |
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