Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

Pancreatic cancer is almost invariably associated with mutations in the KRAS gene, most commonly KRAS(G12D), that result in a dominant-active form of the KRAS GTPase. However, how KRAS mutations promote pancreatic carcinogenesis is not fully understood, and whether oncogenic KRAS is required for the...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Collins, Meredith A., Bednar, Filip, Zhang, Yaqing, Brisset, Jean-Christophe, Galbán, Stefanie, Galbán, Craig J., Rakshit, Sabita, Flannagan, Karen S., Adsay, N. Volkan, Pasca di Magliano, Marina
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2012
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266788/
https://ncbi.nlm.nih.gov/pubmed/22232209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59227
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