Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

Pancreatic cancer is almost invariably associated with mutations in the KRAS gene, most commonly KRAS(G12D), that result in a dominant-active form of the KRAS GTPase. However, how KRAS mutations promote pancreatic carcinogenesis is not fully understood, and whether oncogenic KRAS is required for the...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Collins, Meredith A., Bednar, Filip, Zhang, Yaqing, Brisset, Jean-Christophe, Galbán, Stefanie, Galbán, Craig J., Rakshit, Sabita, Flannagan, Karen S., Adsay, N. Volkan, Pasca di Magliano, Marina
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266788/
https://ncbi.nlm.nih.gov/pubmed/22232209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59227
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk