Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion

BACKGROUND & AIMS: Developmental morphogens play an important role in coordinating the ductular reaction and portal fibrosis occurring in the setting of cholangiopathies. However, little is known about how membrane signaling events in ductular reactive cells (DRCs) are transduced into nuclear tr...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jalan-Sakrikar, Nidhi, De Assuncao, Thiago M., Lu, Jie, Almada, Luciana L., Lomberk, Gwen, Fernandez-Zapico, Martin E., Urrutia, Raul, Huebert, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148157/
https://ncbi.nlm.nih.gov/pubmed/27936185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168266
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